RNA-Induced Chromatin Remodeling and DNA Melting during Selective Gene Transcription.

RNA-Induced Chromatin Remodeling and DNA Melting during Selective Gene Transcription.

     Small nuclear RNA species function as de-repressors by displacing repressor proteins (dark blocks), and then binding to the anti-template DNA strand at an initiation site. This initiation stage frees the template DNA strand for transcription to gene-specific pre-messenger RNA, following the recruitment to that site, of RNA polymerase II and other transcription factors such as TFIIH.

     A specific de-repressor RNA sequence may interact with complementary DNA sequences at several gene loci, permitting one RNA sequence population to activate multiple genes synchronously.

     An excessive synthesis of gene-specific  pre-messenger RNA may result in formation of RNA-RNA duplexes between the de-repressor RNA and the 5’ leader sequences of that pre-messenger RNA, removing the de-repressor RNA from that initiation site, and reducing the pre-messenger RNA synthesis at that site in a feedback mechanism for control of selective gene dosage.

     Melted DNA initiation sites are targets for early DNA replication, for single- and double-strand radiation breaks, and for the intercalation of polycyclic hydrocarbons, viral oncogenes or RNA.
 

Return to:  "Activator RNA Exchange during Interphase Chromatin Reprogramming".

Return to:  "Subjects of Study in Cell and Chromatin Reprogramming":

Summary of:  "Activator RNA Exchange during Interphase Chromatin Reprogramming".

Further Topics in:  Euchromatin,  active DNA, and  RNA  ribo-regulators:

Links to Euchromatin Activator RNA Reviews:
Links to Euchromatin Activator RNA Research:
Links to Ultrastructural Probes of DNase I-Sensitive Sites:
Links to RNA as a Therapeutic Agent:
Links to Hodgkin Lymphoma Immuno-Pathology:
Links to Activated T-Lymphocyte Immunotherapy:
Links to Medical Systems Biology:

"Ultrastructural Probes of Active DNA Sites, and the RNA Activators of DNA".

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