"RNA Reigns in Neurons".

Henri Tiedge*

SUNY Health Science Center Brooklyn, Department of Physiology and Pharmacology, Department of Neurology, 450 Clarkson Avenue, Brooklyn, New York 11203

*Correspondence:
Henri Tiedge
Ph: 718 270 1370; Fax: 718 270 2444
htiedge@downstate.edu

A workshop entitled “RNA Control of Neuronal Function” was recently held in Kfar Blum, Israel. The main topics discussed at the meeting included neuronal RNA targeting mechanisms and the contributing codes and components, translational control mechanisms in dendrites and axons, and the relevance of these mechanisms for neuronal development, plasticity, and dysfunction.

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Koekkoek, S.K., Yamaguchi, K., Milojkovic, B.A., Dortland, B.R., Ruigrok, T.J., Maex, R., De Graaf, W., Smit, A.E., Vanderwerf, F., Bakker, C.E. et al. (2005). Deletion of FMR1 in purkinje cells enhances parallel fiber LTD, enlarges spines, and attenuates cerebellar eyelid conditioning in fragile X syndrome. Neuron 47, 339-352.

Muslimov, I.A., Titmus, M., Koenig, E., and Tiedge, H. (2002). Transport of neuronal BC1 RNA in Mauthner axons. J. Neurosci. 22, 4293-4301.

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The nervous system and its brain now show the mobility as well as the diversity of RNA species. Its most active region, the cerebral cortex, is alive with embryonic expression. And neural gene expression is often dependent upon RNA de-repressors of repressed genes.

1. Kuwabara T, Hsieh J, Nakashima K, Warashina M, Taira K, and Gage FH,
"The NRSE smRNA specifies the fate of adult hippocampal neural stem cells".

2. Zapala MA, Hovatta I, Ellison JA, Wodicka L, Del Rio JA, Tennant R, Tynan W, Broide RS, Helton R, Stoveken BS, Winrow C, Lockhart DJ, Reilly JF, Young WG, Bloom FE, Lockhart DJ, and Barlow C,
"Adult mouse brain gene expression patterns bear an embryologic imprint".

3. Song X, Sun Y, and Garen A, "Roles of PSF protein and VL30 RNA in reversible gene regulation".

4. Kuwabara T, Hsieh J, Nakashima K, Taira K, and Gage FH, "A Small Modulatory dsRNA Specifies the Fate of Adult Neural Stem Cells".

5. Hovsepian JA, and Frenster JH, "Sense and antisense during RNA initiation of the DNA transcription bubble".

Links to RNA and Biological Causality:

Links to Euchromatin Activator RNA Reviews:
Links to Euchromatin Activator RNA Research:
Links to Ultrastructural Probes of DNase I-Sensitive Sites:
Links to RNA as a Therapeutic Agent:
Links to Hodgkin Lymphoma Immuno-Pathology:
Links to Activated T-Lymphocyte Immunotherapy:
Links to Medical Systems Biology:
Links to Selective Gene Transcription:
Links to RNA-Induced Epigenetics:
Links to RNA-Induced Embryogenesis:
Links to RNA and Biological Causality:
Links to Reprogramming and Neoplasia:

A Brief History of Activator RNA:

"Ultrastructural Probes of Active DNA Sites, and the RNA Activators of DNA". (PowerPoint Presentation).